Jaganath, D, Saito, M, Gilman, RH et al. (8 more authors) (2014) First detected Helicobacter pylori infection in infancy modifies the association between diarrheal disease and childhood growth in Peru. Helicobacter, 19 (4). 272 - 279. ISSN 1083-4389
Abstract
BACKGROUND: In endemic settings, Helicobacter pylori infection can occur shortly after birth and may be associated with a reduction in childhood growth. MATERIALS AND METHODS: This study investigated what factors promote earlier age of first H. pylori infection and evaluated the role of H. pylori infection in infancy (6-11 months) versus early childhood (12-23 months) on height. We included 183 children near birth from a peri-urban shanty town outside of Lima, Peru. Field-workers collected data on socioeconomic status (SES), daily diarrheal and breast-feeding history, antibiotic use, anthropometrics, and H. pylori status via carbon 13-labeled urea breath test up to 24 months after birth. We used a proportional hazards model to assess risk factors for earlier age at first detected infection and linear mixed-effects models to evaluate the association of first detected H. pylori infection during infancy on attained height. RESULTS: One hundred and forty (77%) were infected before 12 months of age. Lower SES was associated with earlier age at first detected H. pylori infection (low vs middle-to-high SES Hazard ratio (HR) 1.59, 95% CI 1.16, 2.19; p = .004), and greater exclusive breast-feeding was associated with reduced likelihood (HR 0.63, 95% CI 0.40, 0.98, p = .04). H. pylori infection in infancy was not independently associated with growth deficits (p = .58). However, children who had their first detected H. pylori infection in infancy (6-11 months) versus early childhood (12-23 months) and who had an average number of diarrhea episodes per year (3.4) were significantly shorter at 24 months (-0.37 cm, 95% CI, -0.60, -0.15 cm; p = .001). DISCUSSION: Lower SES was associated with a higher risk of first detected H. pylori infection during infancy, which in turn augmented the adverse association of diarrheal disease on linear growth.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014, John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Jaganath, D., Saito, M., Gilman, R. H., Queiroz, D. M.M., Rocha, G. A., Cama, V., Cabrera, L., Kelleher, D., Windle, H. J., Crabtree, J. E. and Checkley, W. (2014), First Detected Helicobacter pylori Infection in Infancy Modifies the Association Between Diarrheal Disease and Childhood Growth in Peru. Helicobacter, 19: 272–279. doi: 10.1111/hel.12130, which has been published in final form at http://dx.doi.org/10.1111/hel.12130. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: | Child; Helicobacter pylori; diarrhea; growth; Animals; Breath Tests; Child Development; Child, Preschool; Developmental Disabilities; Diarrhea; Female; Helicobacter Infections; Helicobacter pylori; Humans; Infant; Infant, Newborn; Male; Peru; Pregnancy; Risk Factors; Social Class; Suburban Population; Urea |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) |
Funding Information: | Funder Grant number EU - European Union 032126 |
Depositing User: | Symplectic Publications |
Date Deposited: | 10 Aug 2015 10:40 |
Last Modified: | 09 Feb 2018 06:11 |
Published Version: | http://dx.doi.org/10.1111/hel.12130 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/hel.12130 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:86684 |