Abbasi, M. and Clayton, R. (2014) Formulation of ATP sensitive K+ Current and Action Potential Shape in Models of Human Ventricular Myocytes. In: Computing in Cardioliogy. Computing in Cardioliogy Conference (CinC), 07-10 Sep 2014, Cambridge, MA (USA). Vol. 41. Institute of Electrical and Electronics Engineers (IEEE), 201 - 204. ISBN: 978-1-4799-4346-3 . ISSN: 2325-8861.
Abstract
The contribution of the ATP-sensitive K+ (KATP+) current to the action potential is an important component of cardiac ischaemia. The purpose of this study was to investigate how the formulation of IK(ATP) influences action potential shape and duration in the Ten Tusscher-Panfilov 2006 model of human ventricular myocytes. We compared four different IK(ATP) formulations, which were inserted in the epicardial variant of the cell model embedded in a 2D monodomain tissue model. The results demonstrate that inserting IK(ATP) in the cell models shortens APD as intracellular ATP concentration is reduced, consistent with experimental findings. Although the current-voltage properties of each IK(ATP) formulation were different, each formulation had a similar effect on the properties of the tissue model.
Metadata
| Item Type: | Proceedings Paper |
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| Authors/Creators: |
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| Copyright, Publisher and Additional Information: | © 2014 IEEE. This is an author produced version of a paper subsequently published in Computing in Cardiology Conference (CinC). Uploaded in accordance with the publisher's self-archiving policy. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works. |
| Keywords: | Computational modeling; Electric potential; Data models; Animals; Myocardium; Biological system modeling; Mathematical model |
| Dates: |
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| Institution: | The University of Sheffield |
| Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Computer Science (Sheffield) |
| Date Deposited: | 08 Oct 2015 15:51 |
| Last Modified: | 03 Jun 2026 15:08 |
| Published Version: | http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumb... |
| Status: | Published |
| Publisher: | Institute of Electrical and Electronics Engineers (IEEE) |
| Refereed: | Yes |
| Identification Number: | ISSN 2325-8861 |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:86348 |
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