Walton, RD, Jones, SA, Rostron, KA et al. (4 more authors) (2016) Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 71 (8). pp. 1005-1013. ISSN 1079-5006
Abstract
With aging, there is a decline in cardiac function accompanying increasing risk of arrhythmias. These effects are likely to be mechanistically associated with age-associated changes in calcium regulation within cardiac myocytes. Previous studies suggest that lifelong exercise can potentially reduce age-associated changes in the heart. Although exercise itself is associated with changes in cardiac function, little is known about the interactions of aging and exercise with respect to myocyte calcium regulation. To investigate this, adult (12 months) and old (24 months) C57/Bl6 mice were trained using moderate-intensity treadmill running. In response to 10 weeks’ training, comparable cardiac hypertrophic responses were observed, although aging independently associated with additional cardiac hypertrophy. Old animals also showed increased L- and T-type calcium channels, the sodium–calcium exchange, sarcoendoplasmic reticulum calcium ATPase, and collagen (by 50%, 92%, 66%, 88%, and 113% respectively). Short-term exercise training increased D-type and T-type calcium channels in old animals only, whereas an increase in sodium–calcium exchange was seen only in adult animals. Long-term (12 months) training generally opposed the effects of aging. Significant hypertrophy remained in long-term trained old animals, but levels of sarcoendoplasmic reticulum calcium ATPase, sodium–calcium exchange, and collagen were not significantly different from those found in the adult trained animals.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Ageing; Exercise; Fibrosis; Hypertrophy; Calcium regulation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Funding Information: | Funder Grant number British Heart Foundation PG/11/15/28775 Wellcome Trust 086998/Z/08/Z BBSRC (Biotechnology & Biological Sciences Research Council) EX470375 |
Depositing User: | Symplectic Publications |
Date Deposited: | 28 May 2015 09:15 |
Last Modified: | 29 Oct 2020 17:20 |
Published Version: | http://dx.doi.org/10.1093/gerona/glv093 |
Status: | Published |
Publisher: | Oxford University Press |
Identification Number: | 10.1093/gerona/glv093 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:86347 |
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