Shepherd, TJ, Dirks, W, Manmee, C et al. (4 more authors) (2012) Reconstructing the life-time lead exposure in children using dentine in deciduous teeth. Science of the Total Environment, 425. pp. 214-222. ISSN 0048-9697
Abstract
Data are presented to demonstrate that the circumpulpal dentine of deciduous teeth can be used to reconstruct a detailed record of childhood exposure to lead. By combining high spatial resolution laser ablation ICP-MS with dental histology, information was acquired on the concentration of lead in dentine from in utero to several years after birth, using a true time template of dentine growth. Time corrected lead analyses for pairs of deciduous molars confirmed that between-tooth variation for the same child was negligible and that meaningful exposure histories can be obtained from a single, multi-point ablation transect on longitudinal sections of individual teeth. For a laser beam of 100 μm diameter, the lead signal for each ablation point represented a time span of 42 days. Simultaneous analyses for Sr, Zn and Mg suggest that the incorporation of Pb into dentine (carbonated apatite) is most likely controlled by nanocrystal growth mechanisms. The study also highlights the importance of discriminating between primary and secondary dentine and the dangers of translating lead analyses into blood lead estimates without determining the age or duration of dentine sampled. Further work is in progress to validate deciduous teeth as blood lead biomarkers.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Deciduous teeth; Dentine; Lead; Exposure history; Laser ablation ICP-MS; Dental histology |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Earth and Environment (Leeds) > Inst of Geophysics and Tectonics (IGT) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Aug 2016 11:11 |
Last Modified: | 08 Nov 2016 22:56 |
Published Version: | https://dx.doi.org/10.1016/j.scitotenv.2012.03.022 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.scitotenv.2012.03.022 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:86172 |