Li, M, Qiu, S, Lu, Y et al. (3 more authors) (2014) Investigation of the Effect of Hydroxypropyl Methylcellulose on the Phase Transformation and Release Profiles of Carbamazepine-Nicotinamide Cocrystal. Pharmaceutical Research, 31 (9). 2312 - 2325. ISSN 0724-8741
Abstract
Purpose: The aim of this work was to investigate the influence of hydroxypropyl methylcellulose (HPMC) on the phase transformation and release profile of carbamazepine-nicotinamide (CBZ-NIC) cocrystal in solution and in sustained release matrix tablets. Methods: The polymorphic transitions of the CBZ-NIC cocrystal and its crystalline properties were examined by differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Raman spectroscopy, and scanning electron microscopy (SEM). Results: The apparent CBZ solubility and dissolution rate of CBZ-NIC cocrystal were constant in different concentrations of HPMC solutions. In a lower percentage of HPMC in the matrix tablets, the CBZ release profile of the CBZ-NIC cocrystal was nonlinear and declined over time. With an increased HPMC content in the tablets, the CBZ-NIC cocrystal formulation showed a significantly higher CBZ release rate in comparison with the other two formulations of CBZ III and the physical mixture. Conclusions: Because of a significantly improved dissolution rate of the CBZ-NIC cocrystal, the rate of CBZ entering into solution is significantly faster than the rate of formation of the CBZ-HPMC soluble complex in solution, leading to a higher supersaturation level of CBZ and subsequently precipitation of CBZ dihydrate.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2014 Springer Science+Business Media New York. This is an author produced version of a paper published in Pharmaceutical Research. Uploaded in accordance with the publisher's self-archiving policy. The original publication is available at www.springerlink.com |
Keywords: | carbamazepine-nicotinamide (CBZ-NIC); cocrystal; hydroxypropyl methylcellulose (HPMC); inhibition; phase transformation; UV imaging |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) > Institute for Particle Science and Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 29 Jul 2015 11:23 |
Last Modified: | 15 Jan 2018 17:26 |
Published Version: | http://dx.doi.org/10.1007/s11095-014-1326-2 |
Status: | Published |
Publisher: | Springer |
Identification Number: | 10.1007/s11095-014-1326-2 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:85995 |