Reilly, G.C. and Edwards, J.H. (2015) Vibration stimuli and the differentiation of musculoskeletal progenitor cells: Review of results in vitro and in vivo. World Journal of Stem Cells, 7 (3). pp. 568-582. ISSN 1948-0210
Abstract
Due to the increasing burden on healthcare budgets of musculoskeletal system disease and injury, there is a growing need for safe, effective and simple therapies. Conditions such as osteoporosis severely impact on quality of life and result in hundreds of hours of hospital time and resources. There is growing interest in the use of low magnitude, high frequency vibration (LMHFV) to improve bone structure and muscle performance in a variety of different patient groups. The technique has shown promise in a number of different diseases, but is poorly understood in terms of the mechanism of action. Scientific papers concerning both the in vivo and in vitro use of LMHFV are growing fast, but they cover a wide range of study types, outcomes measured and regimens tested. This paper aims to provide an overview of some effects of LMHFV found during in vivo studies. Furthermore we will review research concerning the effects of vibration on the cellular responses, in particular for cells within the musculoskeletal system. This includes both osteogenesis and adipogenesis, as well as the interaction between MSCs and other cell types within bone tissue.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial Licence (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use the material for commercial purposes. |
Keywords: | Mesenchymal stem cells; Mechanobiology; Osteogenesis; Whole body vibration; Adipogenesis; osteoporosis; Low magnitude; high frequency vibration loading |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Materials Science and Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 05 May 2015 10:22 |
Last Modified: | 05 May 2015 10:22 |
Published Version: | http://dx.doi.org/10.4252/wjsc.v7.i3.568 |
Status: | Published |
Publisher: | Baishideng Publishing Group Co. Limited |
Refereed: | Yes |
Identification Number: | 10.4252/wjsc.v7.i3.568 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:85629 |