Lilley, M., Mambwe, B., Thompson, M.J. et al. (2 more authors) (2015) 4-Phosphopyrazol-2-yl alanine: a non-hydrolysable analogue of phosphohistidine. Chemical Communications, 51. 7305 - 7308.
Abstract
We report the synthesis of a stable analogue of τ-phosphohistidine: 4-phosphopyrazol-2-yl alanine (). Polyclonal antibodies generated against the mimic show high reactivity and selectivity for τ-phosphohistidine, with minor or no cross-reactivity towards non-phosphorylated histidine or O-phosphoamino acids, including phosphotyrosine.
Metadata
| Item Type: | Article |
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| Authors/Creators: |
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| Copyright, Publisher and Additional Information: | © 2015 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Dates: |
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| Institution: | The University of Sheffield |
| Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection and Immunity (Sheffield) |
| Depositing User: | Symplectic Sheffield |
| Date Deposited: | 05 May 2015 12:55 |
| Last Modified: | 03 Nov 2016 01:57 |
| Published Version: | http://dx.doi.org/10.1039/c5cc01811k |
| Status: | Published |
| Publisher: | Royal Society of Chemistry |
| Refereed: | Yes |
| Identification Number: | 10.1039/c5cc01811k |
| Related URLs: | |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:85550 |
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