Smith, GA, Fearnley, GW, Harrison, MA et al. (3 more authors) (2015) Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease. Journal of Inherited Metabolic Disease, 38 (4). 753 - 763. ISSN 0141-8955
Abstract
Vascular endothelial growth factors (VEGFs) bind to VEGF receptor tyrosine kinases (VEGFRs). The VEGF and VEGFR gene products regulate diverse regulatory pathways in mammalian development, health and disease. The interaction between a particular VEGF and its cognate VEGFR activates multiple signal transduction pathways which regulate different cellular responses including metabolism, gene expression, proliferation, migration, and survival. The family of VEGF isoforms regulate vascular physiology and promote tissue homeostasis. VEGF dysfunction is implicated in major chronic disease states including atherosclerosis, diabetes, and cancer. More recent studies implicate a strong link between response to VEGF and regulation of vascular metabolism. Understanding how this family of multitasking cytokines regulates cell and animal function has implications for treating many different diseases.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 28 Sep 2015 15:18 |
Last Modified: | 29 Sep 2015 14:52 |
Published Version: | http://dx.doi.org/10.1007/s10545-015-9838-4 |
Status: | Published |
Publisher: | Springer Verlag |
Identification Number: | 10.1007/s10545-015-9838-4 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:85485 |