Loftus, H. and Ong, A.C.M. (2012) Cystic kidney diseases: many ways to form a cyst. Pediatric Nephrology, 28 (1). 33 - 49. ISSN 0931-041X
Abstract
Renal cysts are a common radiological finding in both adults and children. They occur in a variety of conditions, and the clinical presentation, management, and prognosis varies widely. In this article, we discuss the major causes of renal cysts in children and adults with a particular focus on the most common genetic forms. Many cystoproteins have been localized to the cilia centrosome complex (CCC). We consider the evidence for a universal ‘cilia hypothesis’ for cyst formation and the evidence for non-ciliary proteins in cyst formation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2012 IPNA. This is an author produced version of a paper subsequently published in Pediatric Nephrology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Renal cysts; Primary cilia; Centrosomes; Ciliopathies |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection and Immunity (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 30 Apr 2015 08:34 |
Last Modified: | 25 Oct 2016 00:01 |
Published Version: | http://dx.doi.org/10.1007/s00467-012-2221-x |
Status: | Published |
Publisher: | Springer Verlag |
Refereed: | Yes |
Identification Number: | 10.1007/s00467-012-2221-x |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:85372 |