Erhayiem, B, Dhingsa, R, Hawkey, CJ et al. (1 more author) (2011) Ratio of visceral to subcutaneous fat area is a biomarker of complicated Crohn's disease. Clinical Gastroenterology and Hepatology, 9 (8). 684-687.e1. ISSN 1542-3565
Abstract
Background & Aims
Fat wrapping and mesenteric hypertrophy are characteristics of Crohn's disease (CD). In patients with CD, mesenteric adipose tissue releases higher levels of adiponectin, which could up-regulate production of tumor necrosis factor-α and increase the risk for aggressive disease. We investigated whether a higher ratio of visceral to subcutaneous fat was associated with complicated (fistulating or stricturing) CD.
Methods
We identified patients with a confirmed diagnosis of CD who had computed tomography scans of their abdomens (n = 50). Areas of subcutaneous and visceral fat were measured in 1 cross-sectional scan that was taken at the level of the umbilicus. The mesenteric fat index (MFI), defined as the ratio of areas of visceral to subcutaneous fat, was compared between patients with complicated (strictures and fistulas) and inflammatory CD.
Results
The mean age of the patients with complications (n = 29) was 49.3 ± 15.6 years, and in patients with inflammatory CD (n = 21) it was 37.7 ± 19.1 years. The MFI was significantly higher (P = .001) in patients with complicated disease (0.67 ± 0.29) than in those with uncomplicated disease (0.23 ± 0.10) and was the only variable that remained significantly different on multivariate analysis. The area under the receiver operating curve for the MFI was 0.95 (95% confidence interval, 0.89–1.0), and an MFI of 0.29 identified patients with complicated CD with 93% sensitivity and 81% specificity.
Conclusions
A high ratio of areas of visceral to subcutaneous fat (MFI) is a marker of aggressive CD. Further studies are needed to determine the roles of adipose tissue in pathogenesis of CD.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | IBD; Prognosis; CT Imaging; TNF |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Division of Biomedical Imaging (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Biomed & Clin Sciences (LIBACS) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 May 2019 13:26 |
Last Modified: | 09 May 2019 13:26 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.cgh.2011.05.005 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:85227 |