Md Yusof, MY, Vital, EM and Emery, P (2013) B-cell-targeted therapies in systemic lupus erythematosus and ANCA-associated vasculitis: Current progress. Expert Review of Clinical Immunology, 9 (8). 761 - 772. ISSN 1744-666X
Abstract
B cells play a central role in the pathogenesis of systemic lupus erythematosus and anti-neutrophil cytoplasmic antibody-associated vasculitis. There are various strategies for targeting B cells including depletion, inhibition of survival factors, activation and inhibition of co-stimulatory molecules. Controlled trials in systemic lupus erythematosus have shown positive results for belimumab, promising results for epratuzumab and negative results for rituximab. The failure of rituximab in controlled trials has been attributed to trial design, sample size and outcome measures rather than true inefficacy. In anti-neutrophil cytoplasmic antibody-associated vasculitis, rituximab is effective for remission induction and in relapsing disease. However, the optimal long-term re-treatment strategy remains to be determined. Over the next 5 years, evidence will be available regarding the clinical efficacy of these novel therapies, biomarkers and their long-term safety.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2013 Informa UK Ltd. This is an author produced version of a paper published in Expert Review of Clinical Immunology. Uploaded in accordance with the publisher's self-archiving policy |
Keywords: | ANCA-associated vasculitis; B cells; belimumab; biologics; rituximab; systemic lupus erythematosus |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Clinical Musculoskeletal Medicine (LIRMM) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Nov 2015 09:52 |
Last Modified: | 16 Nov 2016 01:31 |
Published Version: | http://dx.doi.org/10.1586/1744666X.2013.816479 |
Status: | Published |
Publisher: | Expert Reviews |
Identification Number: | 10.1586/1744666X.2013.816479 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:85076 |