Paterson, T., Sherborne, C., Chen, C. C. et al. (2 more authors) (2014) Manufacturing of PolyHIPE-based Porous Microparticles for Bone Tissue Engineering. In: The University of Sheffield Engineering Symposium Conference Proceedings Vol. 1. USES 2014 - The University of Sheffield Engineering Symposium, 24 June 2014, The Octagon Centre, University of Sheffield.
Abstract
Particle-based systems have great potential as scaffolds for tissue engineering, since they are injectable, avoiding the need for open surgery. When a bone cancer is removed, the void that’s formed requires filling with a biomaterial to encourage bone regrowth. Two main methods of filling these voids include using autograft material or bone ceramics. Injectable cell-scaffolds allow keyhole surgery which would be impossible with current methods of treatment. Here we are investigating a method for production of spherical microporous particles of 100-800 µm. The microporous material is constructed from a HIPE (High Internal Phase Emulsion) via photocuring. The stir-emulsion method produces a wide range of particle sizes and the T-junction fluidic device produces a very narrow range of particle sizes. With both methods it is possible to change the mean particle size and the particle size distribution. The porosity of the particles can be altered independently by the use of temperature during the initial polyHIPE formation. Mesenchymal hES-MPs cells were cultured on particles which had been coated with acrylic acid via plasma deposition. The cells enable the agglomeration of particles into 3D structures with cell growth both into and between particles.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Keywords: | Micro-particle; Mesencymal hES-MP; Particles ; PolyHIPE; Tissue engineering |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > USES (University of Sheffield Engineering Symposium) |
Depositing User: | Repository Officer |
Date Deposited: | 15 Apr 2015 13:40 |
Last Modified: | 21 Apr 2015 10:17 |
Status: | Published |
Identification Number: | 10.15445/01012014.111 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:85060 |