Gordon, VD, Beales, PA, Shearman, GC et al. (4 more authors) (2014) Solid-Like Domains in Mixed Lipid Bilayers. Effect of Membrane Lamellarity and Transition Pathway. Advances in Planar Lipid Bilayers and Liposomes, 20. 137 - 154. ISSN 1554-4516
Abstract
We present optical observations of phase separation in mixed model membranes in the form of giant unilamellar vesicles. These observations are compared to the phase behavior of lipid mixtures, which we determined by X-ray scattering and differential scanning calorimetry or extracted from the existing literature. The domain properties are affected not only by the bulk phase behavior but also by the membrane lamellarity and phase transition pathways. These observations have important implications for how phase behavior determined by bulk methods using dense, multilamellar lipid bilayers are linked to phase separation in giant, unilamellar lipid bilayers as observed by microscopy.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Lipids; Phases; Phase separation; Microscopy; X-ray scattering; Differential scanning calorimetry |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Physical Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 20 Oct 2015 08:20 |
Last Modified: | 20 Oct 2015 08:20 |
Published Version: | http://dx.doi.org/10.1016/B978-0-12-418698-9.00005... |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/B978-0-12-418698-9.00005-8 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:85032 |