Farr, J.N., Zhang, W., Jacques, R.M. et al. (3 more authors) (2014) Altered Cortical Microarchitecture and Bone Metabolism in Patients with Monoclonal Gammopathy of Undetermined Significance. Blood, 123 (5). ISSN 0006-4971
Abstract
Patients with monoclonal gammopathy of undetermined significance (MGUS) are at increased fracture risk, and we have previously shown that MGUS patients have altered trabecular bone microarchitecture compared with controls. However, there are no data on whether the porosity of cortical bone, which may play a greater role in bone strength and the occurrence of fractures, is increased in MGUS. Thus, we studied cortical porosity and bone strength (apparent modulus) using high-resolution peripheral quantitative computed tomography imaging of the distal radius in 50 MGUS patients and 100 age-, gender-, and body mass index–matched controls. Compared with controls, MGUS patients had both significantly higher cortical porosity (+16.8%; P < .05) and lower apparent modulus (–8.9%; P < .05). Despite their larger radial bone size, MGUS patients have significantly increased cortical bone porosity and reduced bone strength relative to controls. This increased cortical porosity may explain the increased fracture risk seen in MGUS patients.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 by The American Society of Hematology. This is an author produced version of a paper subsequently published in Blood. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 31 Mar 2015 13:12 |
Last Modified: | 21 Mar 2018 06:44 |
Published Version: | http://dx.doi.org/ 10.1182/blood-2013-05-505776 |
Status: | Published |
Publisher: | American Society of Hematology |
Refereed: | Yes |
Identification Number: | 10.1182/blood-2013-05-505776 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:84619 |