Bunce, D orcid.org/0000-0003-3265-2700, Bielak, AA, Anstey, KJ et al. (3 more authors) (2014) APOE genotype and cognitive change in young, middle-aged, and older adults living in the community. Journal of Gerontology Series A: Biological Sciences and Medical Sciences, 69 (4). pp. 379-386. ISSN 1079-5006
Abstract
We examined whether the apolipoprotein E (APOE) ε4 allele was associated with cognitive benefits in young adulthood and whether it reversed to confer cognitive deficits in later life ("antagonistic pleiotropy") in the absence of dementia-related neuropathology. We also tested whether the ε2 allele was associated with disadvantages in early adulthood but offered protection against cognitive decline in early old age. Eight-year cognitive change was assessed in 2,013 cognitively normal community-dwelling adults aged 20-24, 40-44, or 60-64 years at baseline. Although cognitive decline was associated with age, multilevel models contrasting the ε2 and ε4 alleles provided no evidence that the APOE genotype was related to cognitive change in any of the age groups. The findings suggest that in the absence of clinically salient dementia pathology, APOE ε2 and ε4 alleles do not exhibit antagonistic pleiotropy in relation to cognition between the ages of 20 and 72 years.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.This is a pre-copyedited, author-produced PDF of an article accepted for publication in The Journals of Gerontology: Series A following peer review. The version of record Bunce, D, Bielak, AA, Anstey, KJ, Cherbuin, N, Batterham, PJ and Easteal, S (2014) APOE genotype and cognitive change in young, middle-aged, and older adults living in the community. Journal of Gerontology Series A: Biological Sciences and Medical Sciences, 69 (4). 379 - 386. ISSN 1079-5006 is available online at: http://dx.doi.org/10.1093/gerona/glt103 |
Keywords: | APOE; Age; Antagonistic pleiotropy; Cognitive change; Dementia.; Adult; Aged; Aging; Apolipoproteins E; Cognition; Cognition Disorders; DNA; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Humans; Middle Aged; Neuropsychological Tests; Risk Factors; Young Adult |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Psychology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 15 May 2015 14:03 |
Last Modified: | 28 Jun 2019 14:23 |
Published Version: | http://dx.doi.org/10.1093/gerona/glt103 |
Status: | Published |
Publisher: | Oxford University Press (OUP) |
Identification Number: | 10.1093/gerona/glt103 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:84449 |