Haynes, R, Bunce, D, Davies, KA et al. (1 more author) (2015) Increased intraindividual reaction time variability in persons with neuropsychiatric manifestations of systemic lupus erythematosus. Archives of Clinical Neuropsychology, 30 (3). 271 - 279. ISSN 0887-6177
Abstract
Systemic Lupus Erythematosus (SLE) can affect multiple organ systems, including the central (CNS) and/or peripheral nervous system. Individuals with nervous system involvement (termed Neuropsychiatric SLE or NPSLE) can present with nonspecific symptoms such as cognitive dysfunction. It is difficult to ascertain whether this is a direct consequence of lupus disease activity on the brain. Intraindividual variability, measured through trial-to-trial reaction time variation, has been proposed as a behavioral marker of CNS integrity. We compared 14 NPSLE, 20 non-NPSLE, and 27 age-matched healthy participants using multiple variability metrics. Variability was increased in NPSLE compared with non-NPSLE participants, and was increased throughout the distribution rather than there being a selective increase in extreme reaction times. Variability metrics were strongly intercorrelated providing convergent evidence that the different metrics are tapping similar processes. The results suggest that there is ongoing disruption to cognitive processing in NPSLE and may indicate small fluctuations in attention.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author 2015. Published by Oxford University Press. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Archives of Clinical Neuropsychology following peer review. The version of record Haynes, R, Bunce, D, Davies, KA and Rusted, JM (2015) Increased intraindividual reaction time variability in persons with neuropsychiatric manifestations of systemic lupus erythematosus. Archives of Clinical Neuropsychology, 30 (3). 271 - 279. ISSN 0887-6177 is available online at: http://dx.doi.org/10.1093/arclin/acv006 |
Keywords: | Intraindividual variability; Reaction time variability; Ex-Gaussian; Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Psychology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 15 May 2015 13:48 |
Last Modified: | 08 Mar 2016 19:07 |
Published Version: | http://dx.doi.org/10.1093/arclin/acv006 |
Status: | Published |
Publisher: | Oxford University Press (OUP) |
Identification Number: | 10.1093/arclin/acv006 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:84445 |