Towey, JJ, Soper, AK and Dougan, L (2013) What happens to the structure of water in cryoprotectant solutions? Faraday Discussions, 167. 159 - 176. ISSN 1359-6640
Abstract
Cryoprotectant molecules are widely utilised in basic molecular research through to industrial and biomedical applications. The molecular mechanisms by which cryoprotectants stabilise and protect molecules and cells, along with suppressing the formation of ice, are incompletely understood. To gain greater insight into these mechanisms, we have completed an experimental determination of the structure of aqueous glycerol. Our investigation combines neutron diffraction experiments with isotopic substitution and computational modelling to determine the atomistic level structure of the glycerol-water mixtures, across the complete concentration range at room temperature. We examine the local structure of the system focusing on water structure. By comparing our data with that from other studies of cryoprotectant solutions, we attempt to find general rules for the action of cryoprotectants on water structure. We also discuss how these molecular scale interactions may be related to the macroscopic properties of the system.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 May 2015 14:07 |
Last Modified: | 01 Aug 2015 09:28 |
Published Version: | http://dx.doi.org/10.1039/c3fd00084b |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/c3fd00084b |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:84385 |