Schaefer, Katrein, Brown, Najmeeyah, Kaye, Paul M orcid.org/0000-0002-8796-4755 et al. (1 more author) (2014) Cervico-vaginal immunoglobulin g levels increase post-ovulation independently of neutrophils. PLoS ONE. e114824. ISSN 1932-6203
Abstract
The prevalence of sexually transmitted infections (STIs) is often higher in females than in males. Although the reproductive cycle profoundly modulates local immunity in the female reproductive tract (FRT) system, significant gaps in our knowledge of the immunobiology of the FRT still exist. An intriguing and frequently observed characteristic of the FRT is the predominant presence of immunoglobulin (Ig) G in cervico-vaginal secretions. We show here that in the mouse, IgG accumulation was enhanced approximately 5-fold post-ovulation, and was accompanied by an influx of neutrophils into the FRT. To determine whether these two events were causally related, we performed short-term neutrophil depletion experiments at individual stages throughout the estrous cycle. Our results demonstrate that neutrophils were not necessary for cycle-dependent tissue remodeling and cycle progression and that cycle-dependent IgG accumulation occurred independent of neutrophils. We thus conclude that neutrophil influx and IgG accumulation are independent events that occur in the FRT during the reproductive cycle.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 Schaefer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Hull York Medical School (York) The University of York > Faculty of Sciences (York) > Centre for Immunology and Infection (CII) (York) |
Depositing User: | Pure (York) |
Date Deposited: | 10 Mar 2015 00:03 |
Last Modified: | 16 Oct 2024 12:29 |
Published Version: | https://doi.org/10.1371/journal.pone.0114824 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1371/journal.pone.0114824 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:84069 |
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Filename: journal.pone.0114824.pdf
Description: Cervico-Vaginal Immunoglobulin G Levels Increase Post-Ovulation Independently of Neutrophils