Chen, Y, Radford, SE and Brockwell, DJ (2015) Force-induced remodelling of proteins and their complexes. Current Opinion in Structural Biology, 30. 89 - 99. ISSN 0959-440X
Abstract
Force can drive conformational changes in proteins, as well as modulate their stability and the affinity of their complexes, allowing a mechanical input to be converted into a biochemical output. These properties have been utilised by nature and force is now recognised to be widely used at the cellular level. The effects of force on the biophysical properties of biological systems can be large and varied. As these effects are only apparent in the presence of force, studies on the same proteins using traditional ensemble biophysical methods can yield apparently conflicting results. Where appropriate, therefore, force measurements should be integrated with other experimental approaches to understand the physiological context of the system under study.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Apr 2015 09:08 |
Last Modified: | 15 Oct 2019 15:14 |
Published Version: | http://dx.doi.org/10.1016/j.sbi.2015.02.001 |
Status: | Published |
Publisher: | Elsevier Ltd |
Identification Number: | 10.1016/j.sbi.2015.02.001 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:84066 |