Aune, D, Navarro Rosenblatt, DA, Chan, DSM et al. (6 more authors) (2015) Anthropometric factors and endometrial cancer risk: A systematic review and dose-response meta-analysis of prospective studies. Annals of Oncology, 26 (8). pp. 1635-1648. ISSN 0923-7534
Abstract
Background: Greater body mass index has been convincingly related to increased endometrial cancer risk, however, whether adiposity earlier in life or abdominal fatness, is an independent risk factor and whether weight gain or greater height increases the risk is not clear. Methods: As part of the Continuous Update Project of the World Cancer Research Fund International we conducted a systematic review and metaanalysis of prospective studies of the association between anthropometric measures and endometrial cancer risk and searched PubMed and several other databases up to February 2015. Summary relative risks were calculated using a random effects model. Results: Thirty prospective studies of BMI and endometrial cancer risk with 22320 cases among 6445402 participants were included. The summary relative risk (RR) for a 5 unit increment was 1.54 (95% CI: 1.47-1.61, I2=81%). Although the test for nonlinearity was significant, pnonlinearity<0.0001, and the curve was steeper within the overweight and obese BMI ranges, there was evidence of increased risk even within the high normal BMI range. The summary RR was 1.45 (95% CI: 1.28- 1.64, I2=76%) per 5 BMI units for BMI in young adulthood, 1.18 (95% CI: 1.14-1.23, I2=67%) per 5 kg increase of weight, and 1.16 (95% CI: 1.12- 1.20, I2=51%) per 5 kg of weight gained between young adulthood and study baseline, 1.27 (95% CI: 1.17-1.39, I2=71%) per 10 cm increase in waist circumference, 1.21 (95% CI: 1.13-1.29, I2=0%) per 0.1 unit increment in waist-to-hip ratio and 1.30 (95% CI: 1.19-1.41, I2=0%) per 10 cm increase in hips circumference. The summary RR was 1.15 (95% I: 1.09-1.22, I2=61%) for a 10 cm increase in height. Conclusions: All measures of adiposity were associated with increased risk of endometrial cancer, and in addition increasing height was associated with increased risk.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author 2015. Published by Oxford University Press on behalf of the European Society for Medical Oncology. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Annals of Oncology following peer review. The definitive publisher-authenticated version Aune, D, Navarro Rosenblatt, DA, Chan, DSM, Vingeliene, S, Abar, L, Vieira, AR, Greenwood, DC, Bandera, EV and Norat, T Anthropometric factors and endometrial cancer risk: A systematic review and dose-response meta-analysis of prospective studies. Annals of Oncology is available online at: http://dx.doi.org/10.1093/annonc/mdv142. |
Keywords: | Body mass index; waist circumference; waist-to-hip ratio; height; weight gain; endometrial cancer |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 Apr 2015 11:40 |
Last Modified: | 06 Nov 2017 08:49 |
Published Version: | http://dx.doi.org/10.1093/annonc/mdv142 |
Status: | Published |
Publisher: | Oxford University Press |
Identification Number: | 10.1093/annonc/mdv142 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:84003 |