Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors of α-helix-mediated protein-protein interactions.
Murphy, NS, Prabhakaran, P, Azzarito, V et al. (5 more authors)
(2013)
Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors of α-helix-mediated protein-protein interactions.
Chemistry - A Eupoean Journal, 19 (18).
5546 - 5550.
ISSN 0947-6539
Abstract
Rapid access to rigid rods: A method is described for the synthesis of 3-O-alkylated aromatic oligobenzamide foldamers that could be used for assembly of libraries of α-helix mimetic inhibitors of protein-protein interactions (see scheme; Fmoc=9-fluorenylmethoxycarbonyl).
Metadata
Item Type:
Article
Authors/Creators:
Murphy, NS
Prabhakaran, P
Azzarito, V
Plante, JP
Hardie, MJ
Kilner, CA
Warriner, SL
Wilson, AJ
Copyright, Publisher and Additional Information:
(c) 2013, Wiley-VCH Verlag. Reproduced in accordance with the publisher's self-archiving policy.
Keywords:
Alkylation; benzamides; chemistry, organic; fluorenes; molecular structure; protein structure, secondary
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)