Barnard, A, Long, K, Yeo, DJ et al. (6 more authors) (2014) Orthogonal functionalisation of α-helix mimetics. Organic and Biomolecular Chemistry, 12 (35). 6794 - 6799. ISSN 1477-0520
Abstract
α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | (c) 2014, Barnard, A, Long, K, Yeo, DJ, Miles, JA, Azzarito, V, Burslem, GM, Prabhakaran, P, Edwards, TA and Wilson, AJ. This is an Open Access article distributed in accordance with the Creative Commons Attribution (CC BY 3.0) licence, which permits others to distribute, remix, adapt, build upon this work, and license their derivative works on different terms, provided the original work is properly cited. |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Mar 2015 12:56 |
Last Modified: | 30 Jun 2020 14:49 |
Published Version: | http://dx.doi.org/10.1039/c4ob00915k |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/c4ob00915k |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:83417 |