Liu, WJ, Ma, CY, Feng, SX et al. (1 more author) (2014) Solubility measurement and stability study of sodium cefuroxime. Journal of Chemical and Engineering Data, 59 (3). 807 - 816. ISSN 0021-9568
Abstract
The stability of sodium cefuroxime has been a major concern since it was invented as a valuable antibiotic. In this study, online attenuated total reflection-fourier transform infrared spectroscopy was applied to monitor the change in supersaturation and optimize the solvent flow rate in antisolvent recrystallization experiments of sodium cefuroxime. The solubility of sodium cefuroxime under various temperatures T, pH values, and solvents was measured and correlated in models. The effect of the antisolvent (79.1 % ethanol) flow rate on crystallinity was examined, and the products were analyzed by X-ray diffraction, scanning electron microscopy, and stability test. The results showed that appropriate mean particle size, uniform particle size distribution, and good crystalline state could improve the stability of sodium cefuroxime. The optimum antisolvent flow rate for this recrystallization process under these operating conditions was found to be 2 mL·min-1.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014, ACS. This is an author produced version of a paper published in Journal of Chemical and Engineering Data. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) > Institute for Particle Science and Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 30 Apr 2015 11:39 |
Last Modified: | 30 Apr 2015 14:43 |
Published Version: | http://dx.doi.org/10.1021/je400938a |
Status: | Published |
Publisher: | American Chemical Society |
Refereed: | Yes |
Identification Number: | 10.1021/je400938a |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:83105 |