Tillu, D.V., Melemedjian, O.K., Asiedu, M.N. et al. (4 more authors) (2012) Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain. Molecular Pain, 8. 5.
Abstract
Despite advances in our understanding of basic mechanisms driving post-surgical pain, treating incision-induced pain remains a major clinical challenge. Moreover, surgery has been implicated as a major cause of chronic pain conditions. Hence, more efficacious treatments are needed to inhibit incision-induced pain and prevent the transition to chronic pain following surgery. We reasoned that activators of AMP-activated protein kinase (AMPK) may represent a novel treatment avenue for the local treatment of incision-induced pain because AMPK activators inhibit ERK and mTOR signaling, two important pathways involved in the sensitization of peripheral nociceptors.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2012 Tillu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | AMP-Activated Protein Kinases; Acute Pain; Animals; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Eukaryotic Initiation Factor-4F; Extracellular Signal-Regulated MAP Kinases; Hyperalgesia; Interleukin-6; Male; Mice; Mice, Inbred ICR; Pain, Postoperative; Protein Biosynthesis; Sensory Receptor Cells; Signal Transduction; Sirtuin 1; Stilbenes; TOR Serine-Threonine Kinases; Time Factors; Trigeminal Ganglion |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 27 Jan 2015 16:41 |
Last Modified: | 27 Jan 2015 16:41 |
Published Version: | http://dx.doi.org/10.1186/1744-8069-8-5 |
Status: | Published |
Publisher: | BioMed Central |
Refereed: | Yes |
Identification Number: | 10.1186/1744-8069-8-5 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:83047 |