Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistance cancer cells
Tian, W, Liu, J, Guo, Y et al. (3 more authors)
(2015)
Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistance cancer cells.
Journal of Materials Chemistry. B, 3 (7).
1204 - 1207 (4).
ISSN 2050-750X
Abstract
Self-assembled micelles of amphiphilic PEG-rapamycin conjugates loaded with paclitaxel have been developed for co-delivery and simultaneous intracellular release of paclitaxel and rapamycin, bypassing the cancer cell drug resistant mechanism and maximising the synergy of dual-drug combinational therapy. This novel nanomedicine offers 20-fold improved potency over free paclitaxel against a model multidrug resistant human breast cancer cell.
Metadata
Item Type:
Article
Authors/Creators:
Tian, W
Liu, J
Guo, Y
Shen, Y
Zhou, D
Guo, S
Copyright, Publisher and Additional Information:
(c) 2015, Tian, W, Liu, J, Guo, Y, Shen, Y, Zhou, D and Guo, S. This is an Open Access article distributed in accordance with the Creative Commons Attribution (CC BY 3.0) licence, which permits others to distribute, remix, adapt, build upon this work, and license their derivative works on different terms, provided the original work is properly cited.
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)