Sudbery, I. orcid.org/0000-0002-5038-0190, Stalker, J., Simpson, J.T. et al. (13 more authors) (2009) Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels. Genome Biology, 10. ARTN R112. ISSN 1474-760X
Abstract
Genome sequences are essential tools for comparative and mutational analyses. Here we present the short read sequence of mouse chromosome 17 from the Mus musculus domesticus derived strain A/J, and the Mus musculus castaneus derived strain CAST/Ei. We describe approaches for the accurate identification of nucleotide and structural variation in the genomes of vertebrate experimental organisms, and show how these techniques can be applied to help prioritize candidate genes within quantitative trait loci.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Sudbery et al.; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Animals; Base Sequence; Chromosomes, Mammalian; Codon, Terminator; Gene Dosage; Genome; Germ-Line Mutation; Liver; Major Histocompatibility Complex; Mice; Mice, Inbred Strains; Polymorphism, Single Nucleotide; Quality Control; Quantitative Trait Loci; RNA, Messenger; Reference Standards; Sequence Analysis, DNA; Sequence Deletion; Triglycerides |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 01 Aug 2016 09:03 |
Last Modified: | 23 Jun 2023 21:43 |
Published Version: | https://dx.doi.org/10.1186/gb-2009-10-10-r112 |
Status: | Published |
Publisher: | BioMed Central |
Refereed: | Yes |
Identification Number: | 10.1186/gb-2009-10-10-r112 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:82727 |