Vieira, AR, Vingeliene, S, Chan, DSM et al. (5 more authors) (2015) Fruits, vegetables, and bladder cancer risk: a systematic review and meta-analysis. Cancer Medicine, 4 (1). pp. 136-146. ISSN 2045-7634
Abstract
Smoking is estimated to cause about half of all bladder cancer cases. Case-control studies have provided evidence of an inverse association between fruit and vegetable intake and bladder cancer risk. As part of the WCRF-AICR Continuous Update Project, we conducted a systematic review and meta-analysis of prospective studies to assess the dose-response relationship between fruit and vegetables and incidence and mortality of bladder cancer. We searched PubMed up to December 2013 for relevant prospective studies. We conducted highest compared with lowest meta-analyses and dose-response meta-analyses using random effects models to estimate summary relative risks (RRs) and 95% confidence intervals (CIs), and used restricted cubic splines to examine possible nonlinear associations. Fifteen prospective studies were included in the review. The summary RR for an increase of 1 serving/ day (80 grams) were 0.97 (95% CI: 0.95-0.99) I2=0%, 8 studies for fruits and vegetables, 0.97 (95% CI: 0.94-1.00, I2=10%, 10 studies) for vegetables and 0.98 (95% CI: 0.96-1.00, I2=0%, 12 studies) for fruits. Results were similar in men and women and in current, former and non-smokers. Amongst fruits and vegetables subgroups, for citrus fruits the summary RR for the highest compared with the lowest intake was 0.87(95% CI: 0.76-0.99, I2 =0%, 8 studies) and for cruciferous vegetables there was evidence of a non-linear relationship (p=0.001). The current evidence from cohort studies is not consistent with a role for fruits and vegetables in preventing bladder cancer.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Fruits; vegetables; bladder cancer; systematic review; meta-analysis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Dec 2014 14:59 |
Last Modified: | 08 Mar 2016 14:36 |
Published Version: | http://dx.doi.org/10.1002/cam4.327 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/cam4.327 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:82408 |