Kotasidis, FA, Tsoumpas, C, Polycarpou, I et al. (1 more author) (2014) A 5D computational phantom for pharmacokinetic simulation studies in dynamic emission tomography. Computerized Medical Imaging and Graphics, 38 (8). 764 - 773. ISSN 0895-6111
Abstract
Introduction: Dynamic image acquisition protocols are increasingly used in emission tomography for drug development and clinical research. As such, there is a need for computational phantoms to accurately describe both the spatial and temporal distribution of radiotracers, also accounting for periodic and non-periodic physiological processes occurring during data acquisition. Methods: A new 5D anthropomorphic digital phantom was developed based on a generic simulation platform, for accurate parametric imaging simulation studies in emission tomography. The phantom is based on high spatial and temporal information derived from real 4D MR data and a detailed multi-compartmental pharmacokinetic modelling simulator. Results: The proposed phantom is comprised of three spatial and two temporal dimensions, including periodic physiological processes due to respiratory motion and non-periodic functional processes due to tracer kinetics. Example applications are shown in parametric [18F]FDG and [15O]H2O PET imaging, successfully generating realistic macro- and micro-parametric maps. Conclusions: The envisaged applications of this digital phantom include the development and evaluation of motion correction and 4D image reconstruction algorithms in PET and SPECT, development of protocols and methods for tracer and drug development as well as new pharmacokinetic parameter estimation algorithms, amongst others. Although the simulation platform is primarily developed for generating dynamic phantoms for emission tomography studies, it can easily be extended to accommodate dynamic MR and CT imaging simulation protocols.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 Elsevier Ltd. NOTICE: this is the author’s version of a work that was accepted for publication in Computerized Medical Imaging and Graphics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Computerized Medical Imaging and Graphics, 38, 8, (2014)] DOI 10.1016/j.compmedimag.2014.06.018 |
Keywords: | MR; Parametric imaging; PET; Phantom; Pharmacokinetics; Respiratory motion; SPECT; Tomography |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Academic Unit of Medical Physics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 Dec 2014 10:47 |
Last Modified: | 26 Aug 2017 06:38 |
Published Version: | http://dx.doi.org/10.1016/j.compmedimag.2014.06.01... |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.compmedimag.2014.06.018 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:82339 |