McNally, RJQ, Basta, NO, Errington, S et al. (3 more authors) (2014) Socioeconomic patterning in the incidence and survival of children and young people diagnosed with malignant melanoma in Northern England. Journal of Investigative Dermatology, 134. 2703 - 2708. ISSN 0022-202X
Abstract
Previous studies have found marked increases in melanoma incidence. The increase among young people in northern England was especially apparent among females. However, overall 5-year survival has greatly improved. The present study aimed to determine whether socioeconomic factors may be involved in both etiology and survival. All 224 cases of malignant melanoma diagnosed in patients aged 10-24 years during 1968-2003 were extracted from a specialist population-based regional registry. Negative binomial regression was used to examine the relationship between incidence and area-based measures of socioeconomic deprivation and small-area population density. Cox regression was used to analyze the relationship between survival and deprivation and population density. There was significantly decreased risk associated with living in areas of higher unemployment (relative risk per 1% increase in unemployment=0.93; 95% confidence interval (CI) 0.90-0.96, P<0.001). Survival was better in less deprived areas (hazard ratio (HR) per tertile of household overcrowding=1.52; 95% CI 1.05-2.20; P=0.026), but this effect was reduced in the period 1986-2003 (HR=0.61; 95% CI 0.40-0.92; P=0.018). This study found that increased risk of melanoma was linked with some aspects of greater affluence. In contrast, worse survival was associated with living in a more deprived area.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 Author (s). This is an author produced version of a paper published in Journal of Investigative Dermatology. Reproduced in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Geography (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Dec 2014 16:09 |
Last Modified: | 05 Aug 2015 17:38 |
Published Version: | http://dx.doi.org/10.1038/jid.2014.246 |
Status: | Published |
Publisher: | Nature Publishing Group |
Identification Number: | 10.1038/jid.2014.246 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:81744 |