Basta, NO, James, PW, Gomez-Pozo, B et al. (3 more authors) (2014) Survival from teenage and young adult cancer in Northern England, 1968-2008. Pediatric Blood and Cancer, 61 (5). 901 - 906. ISSN 1545-5009
Abstract
Background: Although cancer is relatively rare in teenagers and young adults (TYAs) aged 15-24 years, it is a major cause of death in this age group. This study investigated survival trends in TYA cancer diagnosed in Northern England, 1968-2008. Methods: Five-year survival was analyzed using Kaplan-Meier estimation for four successive time periods. Cox regression analysis was used to investigate associations with demographic factors. Results: The study included 2,987 cases (1,634 males, 1,353 females). Five-year survival for all patients with cancer improved greatly from 46% in 1968-1977 to 84% in 1998-2008 (P<0.001), for patients with leukemia from 2% to 71% (P<0.001), lymphoma from 66% to 86% (P<0.001), central nervous system tumors from 53% to 84% (P<0.001), bone tumors from 29% to 72% (P<0.001), germ cell tumors from 39% to 94% (P<0.001), melanoma and skin cancer from 64% to 100% (P<0.001), and carcinomas from 48% to 80% (P<0.001). Cox analysis showed that for all patients with cancer, survival was better for females than males (HR=0.83; 95% CI 0.74-0.94, P<0.001), for patients aged 20-24 years compared with those aged 15-19 years (HR=0.84; 95% CI 0.75-0.94, P=0.002), but survival was worse for patients who resided in more deprived areas (HR=1.06; 95% CI 1.01-1.11, P=0.025). Conclusion: There have been large improvements in TYA cancer survival in Northern England over the last four decades. Future work should determine factors that could lead to even better survival, including possible links with delayed diagnosis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2014 Wiley Periodicals, Inc. This is an author produced version of a paper published in Pediatric Blood and Cancer. Uploaded in accordance with the publisher's self-archiving policy |
Keywords: | Cancer; Leukemia; Lymphoma; Solid tumors; Survival; Teenagers and young adults |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Geography (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 Jan 2015 16:37 |
Last Modified: | 08 May 2015 13:06 |
Published Version: | http://dx.doi.org/10.1002/pbc.24939 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/pbc.24939 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:81738 |