Liu, WJ, Ma, CY, Liu, JJ et al. (2 more authors) (2015) Analytical technology aided optimization and scale-up of impinging jet mixer for reactive crystallization process. AIChE Journal, 61 (2). 503 - 517. ISSN 0001-1541
Abstract
Reactive crystallization is widely used in the manufacture of active pharmaceutical ingredients (APIs). Since APIs often have low solubility, traditional stirred tank reactors and the route of process operation and control using metastable zone width are not effective. The current work investigated the integration of an impinging jet mixer and a stirred tank crystallizer that can take advantage of both the reaction and crystallization characteristics, the focus being on design optimization and scale-up using process analytical techniques based on the Fourier transform Infrared spectroscopy and Focused Beam Reflectance Measurement, as well as X-ray diffraction and particle imaging Morphologi G3. The parameters for process operation and design of the impinging jet mixer were optimized. The research was carried out with reference to the manufacture of an antibiotic, sodium cefuroxime, firstly in a 1L reactor, then a 10L reactor. The crystals produced showed higher crystallinity, narrower size distribution, higher stability and purity.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2014 American Institute of Chemical Engineers. This is the peer reviewed version of the following article: Liu, WJ, Ma, CY, Liu, JJ, Zhang, Y and Wang, XZ (2015) Analytical technology aided optimization and scale-up of impinging jet mixer for reactive crystallization process. AIChE Journal, 61 (2). 503 - 517., which has been published in final form at http://dx.doi.org/10.1002/aic.14662. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) > Institute for Particle Science and Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Aug 2015 13:48 |
Last Modified: | 08 Nov 2015 23:36 |
Published Version: | http://dx.doi.org/10.1002/aic.14662 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/aic.14662 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:81325 |