McLean, SL, Blenkinsopp, A and Bennett, MI (2013) Using haloperidol as an antiemetic in palliative care: informing practice through evidence from cancer treatment and postoperative contexts. Journal of Pain and Palliative Care Pharmacotherapy, 27 (2). 132 - 135. ISSN 1536-0288
Abstract
Nausea and vomiting are common symptoms in palliative care. Haloperidol is often used as an antiemetic in this context, although direct evidence supporting this practice is limited. To evaluate the efficacy and clinical use of haloperidol as an antiemetic in nonpalliative care contexts to inform practice, the authors conducted a rapid review of (i) published evidence to supplement existing systematic reviews, and (ii) practical aspects affecting the use of haloperidol including formulations and doses that are commonly available internationally. In nausea and vomiting related to cancer treatment, haloperidol was superior to control in two small studies. In postoperative nausea and vomiting (PONV), two randomized controlledtrials found treatment with haloperidol comparable to ondansetron. In palliative care, an observational study found a complete response rate of 24% with haloperidol (one in four patients) which would be consistent with a number needed to treat (NNT) of 3 to 5 derived from PONV. There remains insufficient direct evidence to definitively support the use of haloperidol for the management of nausea and vomiting in palliative care. However, generalizing evidence from other clinical contexts may have some validity.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Haloperidol; nausea; palliative care; postoperative nausea and vomiting; vomiting |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Health Sciences (Leeds) > Academic Unit of Primary Care (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Nov 2014 12:24 |
Last Modified: | 04 Nov 2016 07:25 |
Published Version: | http://dx.doi.org/10.3109/15360288.2013.782937 |
Status: | Published |
Publisher: | Informa Healthcare |
Identification Number: | 10.3109/15360288.2013.782937 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:81306 |