Crowley, RK, Hughes, B, Gray, J et al. (7 more authors) (2014) Longitudinal changes in glucocorticoid metabolism are associated with later development of adverse metabolic phenotype. European Journal of Endocrinology, 171 (4). pp. 433-442. ISSN 0804-4643
Abstract
OBJECTIVE: Dysregulation of enzymes that control local tissue steroid metabolism has been implicated in the pathogenesis of obesity and insulin resistance; however, longitudinal changes in glucocorticoid metabolism have not been investigated. This study was performed to evaluate the role of glucocorticoid metabolism in the development of insulin resistance and obesity and to identify biomarkers for future development of metabolic disease. DESIGN: This was a prospective longitudinal observation study conducted over 5 years. METHODS: A 24-h collection was used to serially analyze urinary glucocorticoid and mineralocorticoid metabolites in 57 obese and overweight patients with no prior diagnosis of diabetes mellitus, recruited from the community. RESULTS: Baseline higher 5α-reductase (5αR) activity, but not 11β-hydroxysteroid dehydrogenase type 1 activity, was predictive of increased fasting insulin at final visit (11.4 compared with 7.4 mU/l in subjects with lower 5αR activity, P<0.05), area under the curve insulin response to oral glucose tolerance test (176.7 compared with 89.1 mU/l.h, P<0.01), and homeostasis model assessment (HOMA2-IR; 1.3 compared with 0.8, P<0.01). Higher total glucocorticoid production was associated with abnormal glucose tolerance and increased BMI. During this study, systolic blood pressure increased (equivalent to ∼1 mmHg/year), as did plasma sodium levels; this evidence of increased mineralocorticoid activity was associated with increased aldosterone metabolites and decreased 11β-hydroxysteroid dehydrogenase type 2 activity. CONCLUSIONS: Increased 5αR activity and glucocorticoid secretion rate over time are linked with the development of metabolic disease, and may represent targets for therapeutic intervention, which merits further study.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | 11-beta-Hydroxysteroid Dehydrogenase Type 1; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Aged; Blood Pressure; Female; Glucocorticoids; Humans; Insulin; Insulin Resistance; Linear Models; Longitudinal Studies; Male; Middle Aged; Mineralocorticoids; Phenotype; Predictive Value of Tests; Prospective Studies |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Jul 2016 11:46 |
Last Modified: | 28 Jul 2016 03:27 |
Published Version: | http://dx.doi.org/10.1530/EJE-14-0256 |
Status: | Published |
Publisher: | BioScientifica |
Identification Number: | 10.1530/EJE-14-0256 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:81092 |