Supple, Megan A., Hines, Heather M., Dasmahapatra, Kanchon Kumar orcid.org/0000-0002-2840-7019 et al. (7 more authors) (2013) Genomic architecture of adaptive color pattern divergence and convergence in Heliconius butterflies. Genome Research. pp. 1248-1257. ISSN 1549-5469
Abstract
Identifying the genetic changes driving adaptive variation in natural populations is key to understanding the origins of biodiversity. The mosaic of mimetic wing patterns in Heliconius butterflies makes an excellent system for exploring adaptive variation using next-generation sequencing. In this study, we use a combination of techniques to annotate the genomic interval modulating red color pattern variation, identify a narrow region responsible for adaptive divergence and convergence in Heliconius wing color patterns, and explore the evolutionary history of these adaptive alleles. We use whole genome resequencing from four hybrid zones between divergent color pattern races of Heliconius erato and two hybrid zones of the co-mimic Heliconius melpomene to examine genetic variation across 2.2 Mb of a partial reference sequence. In the intergenic region near optix, the gene previously shown to be responsible for the complex red pattern variation in Heliconius, population genetic analyses identify a shared 65-kb region of divergence that includes several sites perfectly associated with phenotype within each species. This region likely contains multiple cis-regulatory elements that control discrete expression domains of optix. The parallel signatures of genetic differentiation in H. erato and H. melpomene support a shared genetic architecture between the two distantly related co-mimics; however, phylogenetic analysis suggests mimetic patterns in each species evolved independently. Using a combination of next-generation sequencing analyses, we have refined our understanding of the genetic architecture of wing pattern variation in Heliconius and gained important insights into the evolution of novel adaptive phenotypes in natural populations.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2013, Published by Cold Spring Harbor Laboratory Press. This article is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/. |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 09 Oct 2014 14:15 |
Last Modified: | 09 Mar 2025 00:05 |
Published Version: | https://doi.org/10.1101/gr.150615.112 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1101/gr.150615.112 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:79905 |
Download
Filename: Supple_et_al_2013_Genome_Res.pdf
Description: Supple et al 2013 Genome Res