Greenwood, DC, Cade, JE, Moreton, JA et al. (7 more authors) (2005) HFE genotype modifies the influence of heme iron intake on iron status. Epidemiology, 16 (6). 802 - 805. ISSN 1044-3983
Abstract
Background: Public health policy to prevent iron deficiency through food fortification or other measures may be disadvantageous to people with hereditary hemochromatosis. Methods: From a cohort of U.K. women, 2531 women were typed for C282Y and H63D mutations in the hemochromatosis gene. These women completed food frequency questionnaires and provided blood for iron status. Results: C282Y homozygotes (n = 31) had serum ferritin concentrations 2.4 times higher (95% confidence interval = 1.9–3.1) than wild types (n = 1774), but heterozygotes (n = 726) were not different from wild types. H63D genotype had no effect on its own. The effect of heme iron intake (from meat, fish, and poultry) was 2.0 times greater (1.2–3.2) on C282Y homozygotes than other groups. Nonheme iron had little effect. Conclusions: There may be scope for dietary intervention in women homozygous for the C282Y mutation. C282Y heterozygotes and H63D homozygotes and heterozygotes have similar serum ferritin concentrations to wild type and need not reduce their meat intake other than as part of a normal healthy diet.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2005, Williams & Wilkins. This is an author produced version of a paper published in Epidemiology. Uploaded in accordance with the publisher's self-archiving policy. This is a non-final version of an article published in final form in Epidemiology. |
Keywords: | iron; HFE genotype |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 15 Jul 2014 11:14 |
Last Modified: | 04 Nov 2017 22:04 |
Published Version: | http://dx.doi.org/10.1097/01.ede.0000181306.85583.... |
Status: | Published |
Publisher: | Williams & Wilkins |
Identification Number: | 10.1097/01.ede.0000181306.85583.ea |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:79729 |