Cohen, N., Soen, Y. and Braun, E. (1998) Spatio-temporal dynamics of networks of heart cells in culture. Physica A, 249 (1). pp. 600-604. ISSN 0378-4371
Abstract
Spontaneous activity of cultured rat ventricular heart cells is studied as a function of cell density and ambient temperature. Three complementary methods are used: calcium fluorescence microscopy (monitoring intracellular free Ca2+ concentrations), real-time motion detection and electrophysiology. Statistical features of beating activity in single cells, small groups of cells and large monolayered networks are characterized and compared. At relatively high temperatures, a gradual transition from stochastic activity at the level of a single cell to regular synchronized beating in large, dense networks is found. Lowering the temperature results in a gradual loss of synchronization and the emergence of spatio-temporal dynamics, expressed by bursts of activity and contractions on many length and time scales.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) |
Depositing User: | Miss Jamie Grant |
Date Deposited: | 12 Mar 2009 18:55 |
Last Modified: | 04 Nov 2016 04:09 |
Published Version: | http://dx.doi.org/10.1016/S0378-4371(97)00521-9 |
Status: | Published |
Publisher: | Elsevier Science |
Identification Number: | 10.1016/S0378-4371(97)00521-9 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:7966 |