Cade, JE, Burley, VJ and Greenwood, DC (2007) Dietary fibre and risk of breast cancer in the UK Women's Cohort Study. International Journal of Epidemiology, 36 (2). 431 - 438. ISSN 0300-5771
Abstract
Summary Background Reports of relationships between dietary fibre intake and breast cancer have been inconsistent. Previous cohort studies have been limited by a narrow range of intakes. Methods Women who developed invasive breast cancer, 350 post-menopausally and 257 pre-menopausally, during 240,959 person years of follow up in the UK Women’s Cohort Study (UKWCS) were studied. This cohort has 35,792 subjects with a wide range of exposure to dietary fibre with intakes of total fibre in the lowest quintile of <20g/day up to >30g/day in the top quintile. Fibre and breast cancer relationships were explored using Cox regression modeling adjusted for measurement error. Effects of fibre, adjusting for confounders were examined for pre and post-menopausal women separately. Results In pre-menopausal, but not post-menopausal women a statistically significant inverse relationship was found between total fibre intake and risk of breast cancer (p for trend = 0.01). The top quintile of fibre intake was associated with a hazard ratio of 0.4850 (95 percent confidence interval (CI) 0.24, 0.9625, 1.00) compared to the lowest quintile. Pre-menopausally, fibre from cereals was inversely associated with risk of breast cancer (p for trend = 0.0503) and fibre from fruit had a borderline inverse relationship (p for trend = 0.09). A further model including dietary folate strengthened the significance of the inverse relationship between total fibre and pre-menopausal breast cancer. Conclusions These findings suggest that in pre-menopausal women, total fibre is protective against breast cancer; in particular fibre from cereals and possibly fruit.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is a pre-copyedited, author-produced PDF of an article accepted for publication in International Journal of Epidemiology following peer review. The definitive publisher-authenticated version Cade, JE, Burley, VJ and Greenwood, DC (2007) Dietary fibre and risk of breast cancer in the UK Women's Cohort Study. International Journal of Epidemiology, 36 (2). 431 - 438 is available online at: http://dx.doi.org/10.1093/ije/dyl295 |
Keywords: | Fibre; breast cancer; cohort |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Jul 2014 09:49 |
Last Modified: | 22 Jan 2018 13:56 |
Published Version: | http://dx.doi.org/10.1093/ije/dyl295 |
Status: | Published |
Publisher: | Oxford University Press, Academic Division |
Refereed: | Yes |
Identification Number: | 10.1093/ije/dyl295 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:79636 |