Cook, MB, Greenwood, DC, Hardie, LJ et al. (2 more authors) (2008) A systematic review and meta-analysis of the risk of increasing adiposity on Barrett's Esophagus. American Journal of Gastroenterology, 103 (2). 292 - 300. ISSN 0002-9270
Abstract
OBJECTIVES: Esophageal adenocarcinoma and its precursor lesion, Barrett's esophagus, are increasing in incidence in western populations. Gastroesophageal reflux disease (GERD) and high body mass index (BMI) are known risk factors, but it is unclear whether BMI mediates its risk on Barrett's esophagus independently. This systematic review and meta-analysis investigated whether increasing BMI is associated with Barrett's esophagus as compared to general population and GERD controls. METHODS: Search strategies were conducted in MEDLINE (U.S. National Library of Medicine, Bethesda, MD) (1966-2005) and EMBASE (Reed Elsevier PLC, Amsterdam, The Netherlands) (1980-2005). Studies to be included were required to present "current" BMI data for consecutively recruited Barrett's esophagus patients and appropriate comparison arms with a minimum number of 30 subjects in each. RESULTS: The literature search produced 5,501 hits from which 295 papers were extracted. Only :10 studies met the criteria for inclusion. The Statistics/Data Analysis (STATA) program was used to conduct random effects meta-analyses. Nine studies comparing the BMI of the Barrett's esophagus and GERD groups produced a pooled odds ratio (OR) of 0.99 per kg/m(2) (95% confidence interval [CI] 0.97-1.01, I-2 = 52%), while the pooled estimate of three studies comparing Barrett's esophagus with general population controls was 1.02 per kg/m(2) (95% CI 1.01-1.04, I-2 = 0%). CONCLUSIONS: Increasing adiposity is only an indirect risk factor of Barrett's esophagus through the precursor lesion of GERD. Hence, BMI status has no predictive value with respect to GERD patients and their risk of progression to Barrett's esophagus.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2008, authors. This is an author produced version of a paper published in American Journal of Gastroenterology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Barrett's Esophagus |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) > Molecular Epidemiology Unit (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) > NYCRIS & Cancer Studies Group (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Jul 2014 13:41 |
Last Modified: | 01 Feb 2018 03:04 |
Published Version: | http://dx.doi.org/10.1111/j.1572-0241.2007.01621.x |
Status: | Published |
Publisher: | Nature Publishing Group |
Refereed: | Yes |
Identification Number: | 10.1111/j.1572-0241.2007.01621.x |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:79617 |