Ruddle, RA, Fateen, W, Treanor, D et al. (2 more authors) (2013) Leveraging wall-sized high-resolution displays for comparative genomics analyses of copy number variation. In: BioVis 2013 - IEEE Symposium on Biological Data Visualization 2013, Proceedings. 2013 IEEE Symposium on Biological Data Visualization (BioVis), 13-14 Oct 2013, Atlanta, Georgia. IEEE , 89 - 96.
Abstract
The scale of comparative genomics data frequently overwhelms current data visualization methods on conventional (desktop) displays. This paper describes two types of solution that take advantage of wall-sized high-resolution displays (WHirDs), which have orders of magnitude more display real estate (i.e., pixels) than desktop displays. The first allows users to view detailed graphics of copy number variation (CNV) that were output by existing software. A WHirD's resolution allowed a 10× increase in the granularity of bioinformatics output that was feasible for users to visually analyze, and this revealed a pattern that had previously been smoothed out from the underlying data. The second involved interactive visualization software that was innovative because it uses a music score metaphor to lay out CNV data, overcomes a perceptual distortion caused by amplification/deletion thresholds, uses filtering to reduce graphical data overload, and is the first comparative genomics visualization software that is designed to leverage a WHirD's real estate. In a field evaluation, a clinical user discovered a fundamental error in the way their data had been processed, and established confidence in the software by using it to 'find' known genetic patterns in hepatitis C-driven hepatocellular cancer.
Metadata
Item Type: | Proceedings Paper |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | (c) 2013, IEEE. This is the publishers draft version of a paper published in Proceedings, 2013 IEEE Symposium on Biological Data Visualization (BioVis). Uploaded in accordance with the publisher's self-archiving policy |
Keywords: | Copy number variation; comparative genomics; wall-sized high-resolution displays; visualization; user interface |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) > Institute for Computational and Systems Science (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 20 Jun 2014 08:37 |
Last Modified: | 19 Dec 2022 13:27 |
Published Version: | http://dx.doi.org/10.1109/BioVis.2013.6664351 |
Status: | Published |
Publisher: | IEEE |
Identification Number: | 10.1109/BioVis.2013.6664351 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:79191 |