Powell, JJ, Bruggraber, SF, Faria, N et al. (7 more authors) (2014) A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity. Nanomedicine: Nanotechnology, Biology and Medicine, 10 (7). pp. 1529-1538. ISSN 1549-9634
Abstract
The 2-5nm Fe(III) oxo-hydroxide core of ferritin is less ordered and readily bioavailable compared to its pure synthetic analogue, ferrihydrite. We report the facile synthesis of tartrate-modified, nano-disperse ferrihydrite of small primary particle size, but with enlarged or strained lattice structure (~2.7Å for the main Bragg peak versus 2.6Å for synthetic ferrihydrite). Analysis indicated that co-precipitation conditions can be achieved for tartrate inclusion into the developing ferrihydrite particles, retarding both growth and crystallization and favoring stabilization of the cross-linked polymeric structure. In murine models, gastrointestinal uptake was independent of luminal Fe(III) reduction to Fe(II) and, yet, absorption was equivalent to that of ferrous sulphate, efficiently correcting the induced anemia. This process may model dietary Fe(III) absorption and potentially provide a side effect-free form of cheap supplemental iron.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Crown Copyright © 2014. Published by Elsevier. This is an open access article under the terms of the Creative Commons Attribution License CC-BY-NA-SA 3.0 |
Keywords: | Bioavailability; Ferrihydrite; Iron deficiency anemia; Iron oxide; Oral iron |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Funding Information: | Funder Grant number EPSRC (Engineering and Physical Sciences Research Council) EP/E059678/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Jun 2014 12:34 |
Last Modified: | 24 Mar 2021 03:37 |
Published Version: | http://dx.doi.org/10.1016/j.nano.2013.12.011 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.nano.2013.12.011 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:78743 |