Alwan, NA, Greenwood, DC, Simpson, NAB et al. (2 more authors) (2010) The relationship between dietary supplement use in late pregnancy and birth outcomes: a cohort study in British women. BJOG: An International Journal of Obstetrics & Gynaecology, 117 (7). 821 - 829. ISSN 1471-0528
Abstract
Please cite this paper as: Alwan N, Greenwood D, Simpson N, McArdle H, Cade J. The relationship between dietary supplement use in late pregnancy and birth outcomes: a cohort study in British women. BJOG 2010; DOI: 10.1111/j.1471-0528.2010.02549.x.Objective To examine the relationship between dietary supplement use during pregnancy and birth outcomes.Design A prospective birth cohort.Setting Leeds, UK.Sample One thousand two hundred and seventy-four pregnant women aged 18201345 years.Methods Dietary supplement intake was ascertained using three questionnaires for the first, second and third trimesters. Dietary intake was reported in a 24-hour dietary recall administered by a research midwife at 8201312 weeks of gestation. Information on delivery details and antenatal pregnancy complications was obtained from the hospital maternity records.Main outcome measures Birthweight, birth centile and preterm birth.Results Reported dietary supplement use declined from 82% of women in the first trimester of pregnancy to 22% in the second trimester and 33% in the third trimester. Folic acid was the most commonly reported supplement taken. Taking any type of daily supplement during any trimester was not significantly associated with size at birth taking into account known relevant confounders. Women taking multivitamin-mineral supplements in the third trimester were more likely to experience preterm birth (adjusted OR = 3.4, 95% CI 1.2, 9.6, P = 0.02).Conclusions Regular multivitamin2013mineral supplement use during pregnancy, in a developed country setting, is not associated with size at birth. However, it appears to be associated with preterm birth if taken daily in the third trimester. The mechanism for this is unclear and our study's findings need confirming by other cohorts and/or trials in developed countries.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | (c) 2010, Alwan, NA, Greenwood, DC, Simpson, NAB, McArdle, HJ and Cade, JE. This is an Open Access article distributed in accordance with the Creative Commons Attribution (CC BY 4.0) licence, which permits others to distribute, remix, adapt, build upon this work, and license their derivative works on different terms, provided the original work is properly cited. |
Keywords: | Birthweight; community trial; dietary supplements; double-blind; fetal-growth; multiple micronutrient supplementation; placebo-controlled trial; pregnancy; pregnancy outcome; preterm birth; randomized controlled-trial; rural nepal; vitamin-c; weight |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 Apr 2014 09:22 |
Last Modified: | 11 Apr 2014 10:32 |
Published Version: | http://dx.doi.org/10.1111/j.1471-0528.2010.02549.x |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/j.1471-0528.2010.02549 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:78326 |