Dew, TP, Wang, G and Williamson, G (2013) Urinary excretion of ginkgolide terpene lactones following acute consumption of Ginkgo biloba extract. Biofactors. ISSN 0951-6433
Abstract
Urinary biomarkers of plant food supplement (PFS) exposure/intake represent an accurate, objective tool for determining PFS consumption in humans with applications ranging from epidemiology to subject compliance in clinical trials. Ginkgo biloba remains one of the worlds most popular PFS, yet few studies have investigated the uptake and metabolism of its primary unique bioactives: the terpene lactones. To this end, we conducted a dual-dose, acute crossover intervention using G. biloba supplements in healthy participants (n = 12). Pooled 24-H urine samples were analyzed by triple quadrupole LC-MS-MS. We observed that bilobalide and ginkgolides A and B were passed into urine intact and in a dose-dependent manner. Low levels of intact ginkgolides C and J were also excreted. To our knowledge, this is the first study to report intact ginkgolide J in urine following oral consumption of ginkgo supplements and is also the first to account for excreted terpene lactones as a proportion of dose. © 2013 BioFactors, 2013.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2013, Wiley. This is an author produced version of a paper published in Biofactors. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Ginkgo biloba; bilobalide; biomarkers of exposure; biomarkers of intake; ginkgolides; terpene lactones; urine |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 31 Mar 2014 12:10 |
Last Modified: | 01 Dec 2014 01:38 |
Published Version: | http://dx.doi.org/10.1002/biof.1151 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/biof.1151 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:78308 |