Erk, T, Renouf, M, Williamson, G et al. (3 more authors) (2014) Absorption and isomerization of caffeoylquinic acids from different foods using ileostomist volunteers. European Journal of Nutrition, 53 (1). 159 - 166. ISSN 1436-6207
Abstract
Background: Polyphenols are thought to play important roles in human nutrition and health but these health effects are dependent on their bioavailability. This study is one of a series with the aim of determining possible effects of food matrices on caffeoylquinic acid (CQA) bioavailability using ileostomy volunteers. Methods: After a CQA-free diet, ileostomists consumed coffee (746 μmol total CQA), and CQAs in excreted ileal fluid were subsequently identified and quantified with HPLC-diode array detection and HPLC-ESI-MS/MS. In our previous studies, other food sources such as cloudy apple juice (CAJ) (358 μmol CQA) and apple smoothie (AS) (335 μmol CQA) were investigated with the same model. Results: Interesterification of CQA from both apple matrices was observed during gastrointestinal passage, whereas CQA consumed in coffee was not influenced by interesterification reactions. In total, 74.3, 22.4, and 23.8 % of the CQA from CAJ, AS, and coffee, respectively, were absorbed or degraded. Conclusion: Our results show that variations in food matrices and variations in phenolic composition have a major influence on intestinal bioavailability and interesterification of the investigated subclass of polyphenols, the CQAs.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014, Springer Verlag. This is an author produced version of a paper published in European Journal of Nutrition. Uploaded in accordance with the publisher's self-archiving policy. The final publication is available at link.springer.com. |
Keywords: | Caffeoylquinic acid; apple juice; apple smoothie; coffee; bioavailability; ileostomy |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 31 Mar 2014 10:53 |
Last Modified: | 01 Mar 2015 01:38 |
Published Version: | http://dx.doi.org/10.1007/s00394-013-0512-z |
Status: | Published |
Publisher: | Springer Verlag |
Refereed: | Yes |
Identification Number: | 10.1007/s00394-013-0512-z |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:78305 |