van Laar, M, McKinney, PA, Stark, DP et al. (7 more authors) (2012) Survival trends of cancer amongst the south Asian and non-south Asian population under 30 years of age in Yorkshire, UK. Cancer Epidemiology: the international journal of cancer epidemiology, detection and prevention, 36 (1). e13 - e18. ISSN 1877-7821
Abstract
Introduction: Several studies have shown differences in survival trends between ethnic groups across adults with cancer in the UK. It is unclear whether these differences exist exclusively in the older adult population or whether they begin to emerge in children and young adults. Methods: Subjects (n = 3534) diagnosed with cancer under 30 years of age in Yorkshire between 1990 and 2005 were analysed. Differences in survival rates for diagnostic subgroups were estimated by ethnic group (south Asian or not) using Kaplan–Meier estimation and Cox regression. Results: When compared to non-south Asians (all other ethnic groups excluding south Asians) a significant increased risk of death was seen for south Asians with leukaemia (hazard ratio (HR) = 1.75; 95% confidence interval (CI) = 1.11–2.76) and lymphoma (HR = 2.05; 95% CI = 1.09–3.87), whereas south Asians with solid tumours other than central nervous system tumours had a significantly reduced risk of death(HR = 0.50; 95% CI = 0.28–0.89). This was independent of socioeconomic deprivation. Conclusion: We found evidence of poorer survival outcomes for south Asians compared to non-south Asian children and young adults with leukaemia and lymphoma, but better outcomes for south Asian children and young adults with other solid tumours. This needs to be explained, and carefully addressed in the on-going development of cancer services.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2012, Elsevier Ltd. All rights reserved. This is an author produced version of a paper published in Cancer Epidemiology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Adolescent; adult; Asia; child; child, preschool; Great Britain; humans; infant; infant, newborn; neoplasms; survival analysis; young adult |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Geography (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Feb 2014 15:19 |
Last Modified: | 15 Sep 2014 01:57 |
Published Version: | http://dx.doi.org/10.1016/j.canep.2011.08.005 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.canep.2011.08.005 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:77804 |