van Laar, M, Feltbower, RG orcid.org/0000-0002-1728-9408, Gale, CP orcid.org/0000-0003-4732-382X et al. (3 more authors) (2014) Cardiovascular sequelae in long-term survivors of young peoples' cancer: a linked cohort study. British Journal of Cancer, 110. pp. 1338-1341. ISSN 0007-0920
Abstract
Background:We aimed to define the incidence and risk of cardiovascular late effects (LEs) identified from inpatient hospital episode statistics (HES) among long-term survivors of cancer in young people by age at diagnosis (0-14 and 15-29 years).Methods:Records from the Yorkshire Specialist Register of Cancer in Children and Young People (1991-2006) were linked to inpatient HES data (1996-2011) to assess rates of cardiovascular LEs. Rates were compared with the general population in Yorkshire using age-sex-matched HES records for the entire region.Results:Of 3247 survivors of cancer, 3.6% had at least one cardiovascular LE. Overall, cardiovascular hospitalisations for the childhood cohort were threefold higher compared with the general population, but did not differ for young adults. For young adults, increased rates were limited to pericardial disease, cardiomyopathy and heart failure, pulmonary heart disease, hypertension and conduction disorders.Conclusions:Survivors of childhood and young adult cancer remain at increased risk of cardiovascular LEs compared with the general population.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2014, Cancer Research UK. All rights reserved. This is an author produced version of a paper published in British Journal of Cancer. Uploaded in accordance with the publisher's self-archiving policy |
Keywords: | Cardivascular; childhood; teenage; survivors; late effects |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Clinical & Population Science Dept (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Epidemiology and Biostatistics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Feb 2014 14:48 |
Last Modified: | 01 Jun 2023 15:54 |
Published Version: | http://dx.doi.org/10.1038/bjc.2014.37 |
Status: | Published |
Publisher: | Cancer Research UK |
Identification Number: | 10.1038/bjc.2014.37 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:77801 |