Quinnell, RJ, Behnke, JM and Keymer, AE (1991) Host specificity of and cross-immunity between two strains of Heligmosomoides polygyrus. Parasitology, 102 (3). 419 - 427. ISSN 0031-1820
Abstract
The infectivity of wild and laboratory strains of Heligmosomoides polygyrus (Nematospiroides dubius) in laboratory mice and in three species of wild British rodent was compared. Wild strains, of the subspecies H. p. polygyrus, were isolated from wild caught Apodemus sylvaticus. Only very low-level infections of the wild strains became established in laboratory mice. Similar worm burdens of the laboratory strain became established in laboratory mice and A. sylvaticus, although infections in A. sylvaticus were more short lived. Cortisone treatment of hosts increased the establishment and survival of the heterologous worm strain to that of the homologous strain. In contrast, neither strain of parasite established in Clethrionomys glareolus or Microtus agrestis, and cortisone treatment of C. glareolus did not increase establishment. Infection of laboratory mice with the wild-strain parasite induced significant immunity to a challenge infection with the laboratory strain.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) Cambridge University Press, 1991. Reproduced with permission from the publisher. |
Keywords: | Analysis of Variance; Animals; Arvicolinae; Cross Reactions; Feces; Female; Fertility; Male; Mice; Mice, Inbred C57BL; Muridae; Nematode Infections; Nematospiroides dubius; Parasite Egg Count; Rodent Diseases |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Jan 2014 17:48 |
Last Modified: | 15 Sep 2014 02:08 |
Published Version: | http://dx.doi.org/10.1017/S0031182000064398 |
Status: | Published |
Publisher: | Cambridge University Press |
Identification Number: | 10.1017/S0031182000064398 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:77527 |