Pritchard, DI, Hooi, DSW, Brown, A et al. (3 more authors) (2007) Basophil competence during hookworm (Necator americanus) infection. American Journal of Tropical Medicine and Hygiene, 77 (5). 860 - 865. ISSN 0002-9637
Abstract
A popular hypothesis to explain parasite survival in the presence of a pronounced T helper 2 phenotype in helminth-parasitized populations has been Fc epsilon RI blockade by parasite-induced polyclonal IgE. To begin to test the hypothesis that Fc epsilon RI-bearing cells would be refractory to activation in parasitized populations, we investigated basophil function in 43 individuals from a hookworm endemic area. Study individuals had high levels of total IgE and eosinophilia and a mean hookworm burden of 2,257 epg. Basophils from all members of this parasitized population were shown to release histamine to a number of agonists, including anti IgE and a hookworm allergen, calreticulin. These data would indicate that Fc epsilon RI blockade at the level of the basophil did not occur in this parasitized population despite the presence of possible immunologic blocking agents. This would suggest that this effector arm of the T helper 2 phenotype remains operative in infected populations.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2007, The American Society of Tropical Medicine and Hygiene. Reproduced in accordance with the publisher's self-archiving policy. |
Keywords: | calreticulin; IgE; responses; T-cells; Papua-New-Guinea; Ancylostoma-Canium; Helminth Infections; Cuticular collagen; endemic area; BALB/C mice |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 19 Mar 2014 10:06 |
Last Modified: | 16 Nov 2016 16:13 |
Status: | Published |
Publisher: | American Society of Tropical Medicine and Hygiene |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:77516 |