Cunningham, S., Bearn, D., Benson, P. et al. (4 more authors) (2011) In search of the sample: Recent experiences of a trial team in Orthodontics. Contemporary Clinical Trials, 32 (4). 530 - 534. ISSN 1551-7144
Abstract
Randomised clinical trials are commonly undertaken in medical and dental research. However, few authors discuss the difficulties associated with such studies, including costs, ethical issues and recruitment of an adequate number of patients. There is little information available on the number of studies which are terminated early as a result of these issues, but it seems likely that at least 10% of clinical studies never reach completion. This paper reviews two nationally funded clinical studies which were terminated early. It highlights the problems associated with patient recruitment and also some issues which may benefit researchers undertaking similar studies in the future.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2011 Elsevier. This is an author produced version of a paper subsequently published in Contemporary Clinical Trials. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 28 Nov 2013 10:11 |
Last Modified: | 28 Mar 2018 18:39 |
Published Version: | http://dx.doi.org/10.1016/j.cct.2011.04.005 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.cct.2011.04.005 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:76701 |