Raiton, B, McLaughlan, J, Smith, PR et al. (2 more authors) (2012) Non-invasive cavitation nuclei trap for histotripsy. In: IEEE International conference on ultrasonics (2012). 2012 IEEE International Ultrasonics Symposium (IUS), 07-10 Oct 2012, Dresden, Germany. IEEE , 995 - 998. ISBN 978-1-4673-4561-3
Abstract
Clinically available thrombolysis techniques are limited by either slow reperfusion (drugs) or invasiveness (catheters), and carry significant risks of bleeding. In this study, the feasibility of using histotripsy as an efficient and non-invasive thrombolysis technique was investigated. Histotripsy fractionates soft tissue through controlled cavitation using focused, short, high-intensity ultrasound pulses. In-vitro blood clots formed from fresh canine blood were treated by histotripsy. The treatment was applied using a focused 1-MHz transducer, with 5-cycle pulses at a pulse repetition rate of 1 kHz. Acoustic pressures varying from 2 – 12 MPa peak negative pressure were tested. Our results show that histotripsy can perform effective thrombolysis with ultrasound energy alone. Histotripsy thrombolysis only occurred at peak negative pressure ≥6 MPa when initiation of a cavitating bubble cloud was detected using acoustic backscatter monitoring. Blood clots weighing 330 mg were completely broken down by histotripsy in 1.5 – 5 minutes. The clot was fractionated to debris with >96% weight smaller than 5 μm diameter. Histotripsy thrombolysis treatment remained effective under a fast, pulsating flow (a circulatory model) as well as in static saline. Additionally, we observed that fluid flow generated by a cavitation cloud can attract, trap, and further break down clot fragments. This phenomenon may provide a non-invasive method to filter and eliminate hazardous emboli during thrombolysis.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Keywords: | Thrombolysis; Histotripsy; Cavitation; Ultrasound Therapy; Pulsed Ultrasound |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Electronic & Electrical Engineering (Leeds) > Institute of Communication & Power Networks (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Dec 2014 11:30 |
Last Modified: | 19 Dec 2022 13:25 |
Published Version: | http://dx.doi.org/10.1109/ULTSYM.2012.0249 |
Status: | Published |
Publisher: | IEEE |
Identification Number: | 10.1109/ULTSYM.2012.0249 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:76007 |