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Boylan, S, Cade, JE, Dolby, VA et al. (17 more authors) (2008) Maternal caffeine intake during pregnancy and risk of fetal growth restriction: a large prospective observational study. British Medical Journal, 337 (a2332). a2332. ISSN 0959-8138
Abstract
OBJECTIVE: To examine the association of maternal caffeine intake with fetal growth restriction. DESIGN: Prospective longitudinal observational study. SETTING: Two large UK hospital maternity units. PARTICIPANTS: 2635 low risk pregnant women recruited between 8-12 weeks of pregnancy. Investigations Quantification of total caffeine intake from 4 weeks before conception and throughout pregnancy was undertaken with a validated caffeine assessment tool. Caffeine half life (proxy for clearance) was determined by measuring caffeine in saliva after a caffeine challenge. Smoking and alcohol were assessed by self reported status and by measuring salivary cotinine concentrations. MAIN OUTCOME MEASURES: Fetal growth restriction, as defined by customised birth weight centile, adjusted for alcohol intake and salivary cotinine concentrations. RESULTS: Caffeine consumption throughout pregnancy was associated with an increased risk of fetal growth restriction (odds ratios 1.2 (95% CI 0.9 to 1.6) for 100-199 mg/day, 1.5 (1.1 to 2.1) for 200-299 mg/day, and 1.4 (1.0 to 2.0) for >300 mg/day compared with <100 mg/day; test for trend P<0.001). Mean caffeine consumption decreased in the first trimester and increased in the third. The association between caffeine and fetal growth restriction was stronger in women with a faster compared to a slower caffeine clearance (test for interaction, P=0.06). CONCLUSIONS: Caffeine consumption during pregnancy was associated with an increased risk of fetal growth restriction and this association continued throughout pregnancy. Sensible advice would be to reduce caffeine intake before conception and throughout pregnancy.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2008, BMJ Publishing Group. Reproduced in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Biostatistics (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Division of Epidemiology & Biostatistics (Leeds) > Molecular Epidemiology Unit (Leeds) |
Depositing User: | Repository Officer |
Date Deposited: | 09 Dec 2013 09:45 |
Last Modified: | 23 Aug 2017 10:59 |
Published Version: | http://dx.doi.org/10.1136/bmj.a2332 |
Status: | Published |
Publisher: | BMJ Publishing Group |
Refereed: | Yes |
Identification Number: | 10.1136/bmj.a2332 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:75611 |
Available Versions of this Item
-
Maternal caffeine intake during pregnancy and risk of fetal growth
restriction: a large prospective observational study. (deposited 15 Dec 2008 13:06)
- Maternal caffeine intake during pregnancy and risk of fetal growth restriction: a large prospective observational study. (deposited 09 Dec 2013 09:45) [Currently Displayed]